Dr Mark Moore


Anesthesia Medications


Mark Moore, MD
Tallahassee Anesthesiology, PA

Anesthesia Medications

Neostigmine Methylsulfate

Neostigmine Methylsulfate
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Neostigmine Methylsulfate: Neostigmine is classified as a cholinergic agent or parasympathomimetic agent. Its effects are similar to those of acetylcholine and acts by stimulating the parasympathetic nervous system. Cholinergic actions include slowing of the heart rate; increased gastrointestinal secretions and motility; increased secretions and contractility of bronchial smooth muscle; increased contractions of the urinary bladder with relaxation of muscle sphincter; increased force of skeletal muscle contraction; sweating; miosis (pupil constriction) and reduction of intraocular pressure; decrease in blood pressure. Neostigmine is used in the symptomatic control of Myasthenia Gravis and may be used postoperatively to treat or prevent urinary retention or distention. During the administration of anesthetic drugs Neostigmine may be given intraoperatively or post-surgically to reverse the effects of nondepolarizing neuromuscular blocking agents such as atracurium.